The Role of Signal Transducer and Activator of Transcription 3 in Bone Homeostasis and Load-Driven Bone Remodeling
10.16156/j.1004-7220.2021.05.24
- VernacularTitle:信号转导与转录活化因子3在骨稳态和机械力介导骨重建中的作用机制
- Author:
Yiwen CUI
1
;
Zilu WANG
1
;
Weiqi LI
1
;
Yingqi CHENG
1
;
Zhiyun YE
1
;
Xinyi GONG
2
;
Siru ZHOU
2
;
Yiling YANG
2
;
Lingyong JIANG
2
Author Information
1. College of Stomatology, Shanghai Jiao Tong University School of Medicine
2. National Clinical Research Center of Stomatology, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Department of Oral and Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
bone homeostasis;
signal transducer and activator of transcription 3(STAT3);
osteoblasts;
osteoclasts
- From:
Journal of Medical Biomechanics
2021;36(5):E818-E823
- CountryChina
- Language:Chinese
-
Abstract:
Bone homeostasis is a relative balance between bone formation and resorption. Signal transducer and activator of transcription 3 (STAT3), which is closely related to bone homeostasis, takes part in multiple intracellular and extracellular signal pathways. STAT3 participates in the process of osteoblast differentiation regulated by several factors. It can also maintain bone homeostasis by regulating the recruitment, differentiation and activation of osteoclasts. In addition, STAT3 is involved in the interaction between osteoblasts and osteoclasts. Patients with STAT3 mutations can have several inherited bone metabolism diseases. Furthermore, STAT3 plays a critical role in load-driven bone remodeling. Mechanical stimulation promotes osteoblast differentiation and bone formation through activating or enhancing STAT3 expression during bone remodeling process. This review summarizes the participation of STAT3 in maintaining bone homeostasis together with its possible mechanisms and discusses the connection between STAT3 and mechanical stimulation in bone remodeling, so as to provide a potential pharmacological target for the treatment of bone diseases.
