Mechanical Heterogeneity of Tumor Tissues and Epithelial-Mesenchymal Transition of Tumor Cells
10.16156/j.1004-7220.2021.04.24
- VernacularTitle:肿瘤组织力学异质性与肿瘤细胞的上皮-间质转化
- Author:
Yuchuan SUN
1
;
Hong LI
1
;
Qing LUO
1
;
Guanbin SONG
1
Author Information
1. Key Laboratory of Biorheology Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University
- Publication Type:Journal Article
- Keywords:
tumor tissue;
mechanical heterogeneity;
invasion and metastasis;
epithelial-mesenchymal transition (EMT)
- From:
Journal of Medical Biomechanics
2021;36(4):E659-E663
- CountryChina
- Language:Chinese
-
Abstract:
In the process of tumor growth, with the proliferation and expansion of cancer cells, the reconstruction of extracellular matrix (ECM) of cancer tissues, the restriction of surrounding tissues and the flow of cancer tissue interstitial fluid, the special stress environment is formed in the tumor tissues. Significant differences are found in the mechanical environment and mechanical characteristics of different regions of tumor tissues, that is, mechanical heterogeneity. The reseach shows that the mechanical properties of tumor tissue invasion frontier areas are more significant and complex. In particular, the epithelial-mesenchymal transition (EMT) of tumor cells also prefers to concentrate on this area. The mechanical stress generated by the invasion front can induce EMT of tumor cells through TWIST1, TGF-β, WNT and other force signal transduction pathways, and promote tumor cell invasion. From the perspective of tumor biomechanics, this review focuses on the relationship between mechanical heterogeneity of tumor cells and EMT, so as to provide the theoretical basis for mechanoenvironment-targeted therapy of tumors.
