The Role and Mechanisms of Mechanical Stimulation in Degeneration of Vertebral Cartilage Endplates
10.16156/j.1004-7220.2021.04.23
- VernacularTitle:力学刺激在椎体软骨终板退变中的作用及机制
- Author:
Shang SUN
1
;
Zhenda ZHAO
1
;
Ai JIANG
1
;
Zhongjun LIU
1
;
Weishi LI
2
;
Chunli SONG
3
;
Huijie LENG
1
Author Information
1. Department of Orthopedics, Peking University Third Hospital
2. Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education
3. Beijing Key Lab of Spine Diseases
- Publication Type:Journal Article
- Keywords:
mechanical stimulation;
cartilage endplate;
chondrocyte;
endplate degeneration;
signal pathways
- From:
Journal of Medical Biomechanics
2021;36(4):E652-E658
- CountryChina
- Language:Chinese
-
Abstract:
The important function of the endplate is to transmit stress and supply nutrition. Endplate degeneration might induce or promote degeneration of the intervertebral disc, causing a series of spine diseases that seriously impair people’s health and life quality. Endplate chondrocytes can respond to mechanical stimulation, which is an important factor affecting endplate degeneration. Inappropriate mechanical stimulation will accelerate endplate degeneration. This review summarized the effects of mechanical stimulation on vertebral endplate chondrocyte apoptosis, synthesis inhibition, calcification, and extracellular matrix degradation. The endplate degeneration induced by mechanical stimulation is regulated by a complex network of signal pathways composed of various signal transduction factors. The signal pathways involved in this review included NF-κB, Wnt, Hedgehog, MAPK, RhoA/Rock-1, AKT/mTOR, TGF-β signaling pathway and miRNA related signals. The interconnection of these pathways was highlighted and summarized. Multiple signaling pathways work together to regulate endplate chondrocyte metabolism, which ultimately leads to the endplate degeneration. This review might shed light on early diagnosis and precise treatment of cartilage endplate degeneration.
