Evaluation on Mechanical Damage of vWF Induced by Shear Stress in BPX-80 Centrifugal Blood Pump
10.16156/j.1004-7220.2021.04.22
- VernacularTitle:BPX-80离心式血泵中剪切力引发血管性血友病因子机械损伤的评价
- Author:
Min ZHONG
1
;
Wanning GE
1
;
Liudi ZHANG
1
;
Xu MEI
1
Author Information
1. Artificial Organ Technology Laboratory, Bio-Manufacturing Research Centre, School of Mechanical and Electrical Engineering, Soochow University
- Publication Type:Journal Article
- Keywords:
ventricular assist device (VAD);
von Willebrand factor (vWF);
blood damage;
non-physiological shear stress
- From:
Journal of Medical Biomechanics
2021;36(4):E646-E651
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the damage of von Willebrand factor (vWF) induced by shear stress in BPX-80 centrifugal blood pump, and determine whether it can be used as a reference pump for vWF damage research. Methods An in vitro hemolysis test platform was established according to the ASTM standards. The BPX-80 centrifugal blood pump was tested for 8 hours by using fresh porcine blood. The hemolysis level and vWF damage of hourly blood samples were then evaluated and compared with the static control group. ResultsThe hemolysis index of BPX-80 was stable and low during the test; vWF polymer with high molecular weight had a small amount of degradation, and showed no significant difference compared with the static control group; there was no significant change in the concentration of vWF antigen, which was basically consistent with the trend of the static control group. Conclusions BPX-80 centrifugal blood pump has good blood compatibility and can be used as the reference pump for vWF damage and hemolysis evaluation, thereby providing guidance for the design and optimization of new blood pumps.
