Comparative Experiment on Physical Properties of Red Blood Cells in Newborn Infants and Elderly People
10.16156/j.1004-7220.2021.04.21
- VernacularTitle:新生婴儿与老年人红细胞物理特性对比实验
- Author:
Qidi LU
1
;
Yin XIONG
2
;
Yiyang SUN
3
;
Jie LIU
1
;
Xinyue LIU
1
;
Qiaodong WEI
1
;
Shixin XU
4
;
Xiaobo GONG
5
Author Information
1. Department of Engineering Mechanics, Shanghai Jiao Tong University
2. Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
3. Department of Data Science，Kunshan Duke University
4. Department of Mathematics, Kunshan Duke University
5. Department of Engineering Mechanics, State Key Laboratory of Ocean Engineering, School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
red blood cells (RBCs);
micropipette aspiration;
total cholesterol;
glycated hemoglobin
- From:
Journal of Medical Biomechanics
2021;36(4):E638-E645
- CountryChina
- Language:Chinese
-
Abstract:
Objective By comparing the physical properties (cell area, volume and elastic modulus) of red blood cells (RBCs) between newborn infants and the elderly over 80 years old, and correlation with the physiological and biochemical parameters such as total cholesterol and glycosylated hemoglobin, the effects of different ages and biochemical parameters on RBC physical properties were analyzed. Methods The mcropipette aspiration was used to measure the surface area, volume and elastic modulus of erythrocytes in newborn infants and the elderly over 80 years old, and the data were analyzed by statistical distribution analysis, correlation analysis and regression analysis. Results The mean values of RBC volume, surface area and elastic modulus in the elderly over 80 years old were smaller than those in newborn infants, and the mean values of RBC mechanical parameters in the same age group were not significantly different. The erythrocytes geometric parameter distribution of newborn infants was more concentrated than that of the elderly, while the elastic modulus distribution of newborn infants was more dispersed than that of the elderly. The mechanical properties of RBCs in newborn infants were highly correlated with the total cholesterol and gestational week; the mechanical properties of RBCs in the elderly were highly correlated with diastolic blood pressure and glycated hemoglobin. Conclusions There are significant differences in physical properties of RBCs between newborn infants and the elderly over 80 years old, and the biochemical parameters that affect physical properties of RBCs at different ages are also different.
