Influences of Cell-ECM Adhesion on Migration of Tumor Cells Regulated by ECM Stiffness: A Model Study
10.16156/j.1004-7220.2021.04.16
- VernacularTitle:基质刚度调节细胞-细胞外基质间黏附对肿瘤细胞迁移影响的模型研究
- Author:
Ying ZHANG
1
;
Yulan WANG
1
;
Kaiqun WANG
1
;
Yan WEI
1
;
Di HUANG
2
,
3
;
Weiyi CHEN
2
,
3
;
Yanhu SHAN
4
Author Information
1. Research Center for Nano-Biomaterials & Regenerative Medicine, College of Biomedical Engineering, Department of Biomedical Engineering，Taiyuan University of Technology
2. Research Center for Nano-Biomaterials & Regenerative Medicine, College of Biomedical Engineering, Department of Biomedical Engineering
3. Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of Biomedical Engineering, Taiyuan University of Technology
4. School of Instrument and Electronics, North University of China
- Publication Type:Journal Article
- Keywords:
tumor cell;
cell growth;
cell migration;
cell adhesion;
extracellular matrix (ECM);
cellular Potts model (CPM)
- From:
Journal of Medical Biomechanics
2021;36(4):E604-E611
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of cell-extracellular matrix (ECM) adhesion on migration of tumor cells regulated by ECM stiffness. Methods The cellular Potts model (CPM) was established to simulate tumor cell growth and cellular immune feedback system. The effects from mechanical behavior of cells on cell-ECM adhesion were observed, and the migration of tumor cells under different ECM was analyzed. Results The ECM stiffness could influence the migration rate of tumor cells. The change of ECM stiffness regulated the adhesion force between cells and ECM, and the change of adhesion force would influence the migration rate of cells. Conclusions The migration and distribution patterns of cells are closely related to the adhesion and stiffness of ECM. The increase in ECM stiffness can effectively promote the migration rate of tumor cells, and the further increase in ECM stiffness inhibits the migration of tumor cells. These findings may further reveal dynamic changes of ECM, adhesion and mechanical performance of tumor cell migration.
