Research Progress on Regulation of Macrophage Polarization by Biomaterial Functionalized Surface
10.16156/j.1004-7220.2021.03.27
- VernacularTitle:生物材料功能化表面对巨噬细胞极化调控的研究进展
- Author:
Yang LIU
1
,
2
;
Wei CHENG
1
,
2
;
Zhongying RUI
3
;
Lingtao ZHANG
1
;
Yunqiang XU
1
;
Xizheng ZHANG
2
;
Ruixin LI
4
Author Information
1. Department of Orthopedics, Tianjin Medical University General Hospital
2. Institute of Medical Service Support, Institute of Systems Engineering, Academy of Military Sciences
3. Department of Nuclear Medicine, Tianjin Medical University General Hospital
4. Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction
- Publication Type:Journal Article
- Keywords:
prosthesis implantation;
functionalized surface;
surface properties;
macrophage polarization
- From:
Journal of Medical Biomechanics
2021;36(3):E465-E471
- CountryChina
- Language:Chinese
-
Abstract:
Prosthetic loosening and periprosthetic inflammation, as serious complications after joint replacement surgery, often require the secondary surgery for repair, which is easy to adversely affect the physical/mental health and economic status of patients.Studies have shown that the functional phenotype expressed by macrophages by different stimuli, namely macrophage polarization state, prolonged M1 polarization can lead to the continuation of long-term inflammation, while timely and effective M2 macrophage phenotype will lead to enhanced osteogenesis and tissue remodeling cytokine secretion and subsequent osseointegration, which play a crucial role in the development and outcome of prosthetic loosening and periprosthetic inflammation.The local micro-environment of extracellular matrix (ECM) is an important factor in the activation, migration, proliferation and fusion of macrophages. Researchers have deeply understood it mainly through the crosstalk between surface properties of biomaterials and macrophages. As an effector cell, macro-phages can perform complex spatiotemporal cellular functional responses by sensing the physical and chemical environment (surface topography, wettability, chemical composition, biological proteins) represented by surface properties of biomaterials.This paper summarizes the recent findings on macrophage polarization and material surface properties.
