Influences of Renal Artery Stenosis Morphology on its Hemodynamics
10.16156/j.1004-7220.2021.03.15
- VernacularTitle:肾动脉狭窄形态对其血流动力学的影响
- Author:
Zhuxiang XIONG
1
;
Ding YUAN
2
;
Tinghui ZHENG
1
;
Yubo FAN
3
Author Information
1. Department of Applied Mechanics, Sichuan University
2. Department of Vascular Surgery, West China Hospital, Sichuan University
3. School of Biological Science and Medical Engineering, Beihang University
- Publication Type:Journal Article
- Keywords:
renal artery stenosis （RAS）;
hemodynamics;
computational fluid dynamics （CFD）;
morphology
- From:
Journal of Medical Biomechanics
2021;36(3):E389-E395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the hemodynamic effects of morphological parameters on renal artery stenosis （RAS）, so as to provide theoretical references for clinical practice. Methods The idealized models of RAS were established, then the hemodynamic effects from morphological parameters of stenosis including its area, symmetry, length and shape on renal artery was explored using computational fluid dynamics （CFD） method. Results The renal perfusion, pressure drop and wall shear stress (WSS) distributions in renal artery were significantly correlated with area stenosis (AS). When the stenosis area increased from 50% to 70%, all hemodynamic parameters changed significantly. In addition, an asymmetrical stenosis resulted in a significant increase of abnormally high WSS and length of recirculation flow in renal artery, but the change of stenosis length or shape only led to marginal changes in hemodynamics. Conclusions Although AS is still the most significant factor to influence hemodynamics in RAS, other morphological parameters, especially asymmetric stenosis, cannot be neglected. Therefore, it is suggested that clinical treatment plans should be a comprehensive evaluation based on these morphological parameters.
