Hardness Properties of Pig Esophageal at Nanoscale Using Atomic Force Microscope

VernacularTitle:利用原子力显微镜探究食管组织纳米尺度下的硬度性能
Author: Chengxiong LIN ¹ ; Wei LIU ¹ ; Jingyang XIE ¹ ; Wei LI ¹
Author Information

1. Tribology Research Institute, Southwest Jiaotong University
Publication Type:Journal Article
Keywords: esophageal tissues; hardness; atomic force microscope (AFM); viscoelasticity
From: Journal of Medical Biomechanics 2021;36(1):E068-E072
CountryChina
Language:Chinese
Abstract: Objective To study the hardness properties of pig esophageal at the nanoscale using atomic force microscope (AFM). Methods The porcine esophagus was chosen as experimental sample to study the hardness properties of esophageal tissues at different loading rates, deflection and dwell time with AFM. Results The hardness of esophageal tissues at the nanoscale was strongly correlated with the loading rate and the deflection, which increased with the increasing loading rate and decreased with the increasing deflection of cantilever. The difference in the hardness was associated with the viscoelasticity and viscoplasticity of esophageal tissues, including contact stress, energy transition and strain plastic gradient. Conclusions The experimental results have important significance for clinical diagnosis, surgical operation and artificial material development, and reveal the changing patterns for mechanical properties of the esophageal tissues at the microscale.