Protective effect of Ganoderma lucidum spore glycopeptide on liver injury in mice
10.11665/j.issn.1000-5048.20210513
- VernacularTitle:灵芝孢子糖肽对小鼠肝损伤的保护作用
- Author:
Peng FENG
1
;
Xuan FEI
;
Yan CHEN
;
Qinglong GUO
;
Weirong FANG
Author Information
1. 中科健康产业集团有限公司
- Publication Type:Journal Article
- Keywords:
Ganoderma lucidum spore glycopeptide;
acute liver injury;
chronic liver injury;
CCl4;
ethanol
- From:
Journal of China Pharmaceutical University
2021;52(5):603-608
- CountryChina
- Language:Chinese
-
Abstract:
Models of acute and chronic liver injury in mice were established using carbon tetrachloride (CCl4) and ethanol to explore the protective effects of Ganoderma lucidum spore glycopeptide on liver injury.Different dosage of Ganoderma lucidum spore glycopeptide (65,130,260 mg/kg) were given by gavage.The liver index and the levels of serum aspartate transaminase (AST) and alanine transaminase (ALT) were determined.The contents of liver interleukin-6 (IL-6), tumor necrosis factor (TNF-α) and inducible nitric oxide synthase (iNOS) were tested by enzyme-linked immunosorbent assay (ELISA).The pathological injury of liver tissue was observed by HE staining.The results showed that Ganoderma lucidum spore glycopeptide could significantly reduce the liver index and the contents of serum AST and ALT in mice of acute and chronic liver injury.In mice of chronic liver injury induced by CCl4, Ganoderma lucidum spore glycopeptide could significantly decrease the contents of liver IL-6, TNF-α and iNOS, and alleviate the pathological damage of liver tissue.Results suggested that Ganoderma lucidum spore glycopeptide might reduce acute and chronic liver injury with anti-inflammatory effects in mice.
