Calcium signal-mediated activation of NLRP3 inflammasome
10.11665/j.issn.1000-5048.20210501
- VernacularTitle:钙离子信号介导Nod样受体蛋白炎性小体激活的研究进展
- Author:
Yu CHEN
1
;
Zhimeng XU
;
Ping LI
Author Information
1. 中国药科大学天然药物活性组分与药效国家重点实验室
- Publication Type:Journal Article
- Keywords:
NLRP3 inflammasome;
calcium signaling;
activation mechanism
- From:
Journal of China Pharmaceutical University
2021;52(5):513-521
- CountryChina
- Language:Chinese
-
Abstract:
Nod-like receptor protein 3 (NLRP3) inflammasome, which is an important component of the innate immune system, can recognize a variety of pathogens and cell damage, induce the secretion of IL-1β and IL-18, and regulate imflammatory response.More and more studies in recent years have shown that Ca2+ signaling plays an important role in NLRP3 inflammasome activation induced by various NLRP3 inflammasome agonists, and is closely related to the occurrence of related diseases.The article reviews the literatures on Ca2+ and NLRP3 inflammasome, focusing on the potential role of Ca2+ signaling in the activation and regulation of NLRP3 inflammasome, to provide new ideas for the treatment of illness caused by NLRP3 inflammasome.
