Development of septic shock and prognostic assessment in critically ill patients with coronavirus disease outside Wuhan, China
10.5847/wjem.j.1920-8642.2021.04.007
- Author:
Ren-qi Yao
1
,
2
Author Information
1. Department of Critical Care Medicine, the Second People&rsquo
2. s Hospital of Shenzhen, Shenzhen 518035, China
- Publication Type:Journal Article
- Keywords:
Severe acute respiratory syndrome coronavirus 2;
Coronavirus disease;
Intensive care unit;
Septic shock;
Immune response
- From:
World Journal of Emergency Medicine
2021;12(4):293-298
- CountryChina
- Language:English
-
Abstract:
BACKGROUND: The study aims to illustrate the clinical characteristics and development of septic shock in intensive care unit (ICU) patients confirmed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and to perform a comprehensive analysis of the association between septic shock and clinical outcomes in critically ill patients with coronavirus disease (COVID-19).
METHODS: Patients confirmed with SARS-CoV-2 infection, who were admitted to the ICU of the Third People’s Hospital of Shenzhen from January 1 to February 7, 2020, were enrolled. Clinical characteristics and outcomes were compared between patients with and without septic shock.
RESULTS: In this study, 35 critically ill patients with COVID-19 were included. Among them, the median age was 64 years (interquartile range [IQR] 59-67 years), and 10 (28.4%) patients were female. The median ICU length of stay was 16 days (IQR 8-23 days). Three (8.6%) patients died during hospitalization. Nine (25.7%) patients developed septic shock in the ICU, and these patients had a significantly higher incidence of organ dysfunction and a worse prognosis than patients without septic shock.
CONCLUSIONS: Septic shock is associated with a poor outcome in critically ill COVID-19 patients and is one of the hallmarks of the severity of patients receiving ICU care. A dysregulated immune response, uncontrolled inflammation, and coagulation disorders are strongly associated with the development and progression of COVID-19-related septic shock.
