Challenges of Engineering Biomimetic Dental and Paradental Tissues
10.1007/s13770-020-00269-1
- Author:
Mohammed E. GRAWISH
1
;
Lamyaa M. GRAWISH
;
Hala M. GRAWISH
;
Mahmoud M. GRAWISH
;
Salwa A. EL-NEGOLY
Author Information
1. Department of Oral Biology, Faculty of Dentistry, Mansoura University, Elgomhouria St., Mansoura 35516, Egypt
- Publication Type:REVIEW ARTICLE
- From:
Tissue Engineering and Regenerative Medicine
2020;17(4):403-421
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND:Loss of the dental and paradental tissues resulting from trauma, caries or from systemic diseasesconsidered as one of the most significant and frequent clinical problem to the healthcare professionals. Great attempts havebeen implemented to recreate functionally, healthy dental and paradental tissues in order to substitute dead and diseasedtissues resulting from secondary trauma of car accidents, congenital malformations of cleft lip and palate or due to acquireddiseases such as cancer and periodontal involvements.METHOD: An extensive literature search has been done on PubMed database from 2010 to 2019 about the challenges ofengineering a biomimetic tooth (BioTooth) regarding basic biology of the tooth and its supporting structures, strategies,and different techniques of obtaining biological substitutes for dental tissue engineering.
RESULTS:It has been found that great challenges need to be considered before engineering biomimetic individual parts of thetooth such as enamel, dentin-pulp complex and periodontium. In addition, two approaches have been adopted to engineer aBioTooth.The first one was to engineer a BioTooth as an individual unit and the other was to engineer a BioToothwith its supporting structures.
CONCLUSION:Engineering of BioTooth with its supporting structures thought to be in the future will replace the traditionaland conventional treatment modalities in the field of dentistry. To accomplish this goal, different cell lines and growthfactors with a variety of scaffolds at the nano-scale level are now in use. Recent researches in this area of interest arededicated for this objective, both in vivo and in vitro. Despite progress in this field, there are still many challenges ahead andneed to be overcome, many of which related to the basic tooth biology and its supporting structures and some others related tothe sophisticated techniques isolating cells, fabricating the needed scaffolds and obtaining the signaling molecules.
