A Study of the Prognostic Factors in Resected Stage I Non-Small Cell Lung Cancer.
- Author:
Chang Suh KIM
1
;
Soo Bong CHUN
;
Sung Rae CHO
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Kosin University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Carcinoma;
non-small cell;
lung;
Neoplasm marker;
nm23
- MeSH:
Blood Vessels;
Carcinoma, Non-Small-Cell Lung*;
Carcinoma, Squamous Cell;
Classification;
Humans;
Lung;
Multivariate Analysis;
Survival Rate
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
1998;31(10):973-981
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: About 30% to 40% of the patients with pathologic stage I non-small cell lung cancer (NSCLC) die within 5 years after complete resection. The identification of poor prognostic factors and the application of additional treatment are very important to improve the survival rate in resected stage I NSCLC. MATERIALS AND METHODS: Sixty-eight (68) patients who had been diagnosed postoperatively between Janury 1989 and December 1995 as having stage I non-small cell lung cancer according to the TNM classification were studied. The postoperative 5-year survival rate was calculated with the Kaplan-Meier method, and clinico-histopathologic factors including age, sex, operative method, type of tumor cell, T factor, grade of the differentiation in a squamous cell carcinoma, invasion of blood vessel and expression of the nm23-H1 protein were investigated and analyzed. RESULTS: The median survival of the entire group of patients was 58+/-3 months, with a 5-year survival of 58.9%. In univariate analysis, invasion of blood vessel and poor differentiation of the tumor cell in a squamous cell carcinoma significantly worsened the survival. In multivariate analysis, invasion of blood vessel and grade of the differentiation of the tumor cells in a squamous cell carcinoma remained independent prognostic factors. High expression of the nm23-H1 protein was related to a high postoperative 5-year survival in comparision with low expression of the nm23-H1 pretein (73.0% vs 50.7%), but there was no statistical significance. CONCLUSIONS: These results highlight the negative prognostic value of poor differentiation of tumor cells in a squamous cell carcinoma and invasion of blood vessel in stage I non-small cell lung cancer. Also, further studies are necessary to be determined prognostic value of the T factor and expression of the nm23 protein in non-small cell lung cancer.
