Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
10.3347/kjp.2021.59.3.297
- Author:
Run-Hui ZHANG
1
;
Runhao JIN
;
Hao DENG
;
Qing-Kun SHEN
;
Zhe-Shan QUAN
;
Chun-Mei JIN
Author Information
1. Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji 133002, China
- Publication Type:Brief Communication
- From:The Korean Journal of Parasitology
2021;59(3):297-301
- CountryRepublic of Korea
- Language:English
-
Abstract:
Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in relieving T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent.
