Effects of Nemonapride on Cognitive and Psychomotor Performance and Sedation in Normal Adults: A Comparison with Chlorpromazine, Haloperidol and Placebo.
- Author:
Bo Hyun YOON
1
;
Jin Sang YOON
;
Sang Wook PARK
Author Information
1. Naju National Mental Hospital, Chonnam, Korea. yoonbh@chollian.dacom.co.kr
- Publication Type:Original Article
- Keywords:
Cognitive and psychomotor performance;
Sedation;
Nemonapride;
Chlorpromazine Haloperidol
- MeSH:
Adult*;
Antipsychotic Agents;
Chlorpromazine*;
Flicker Fusion;
Haloperidol*;
Humans;
Hypnotics and Sedatives;
Male;
Psychomotor Performance*;
Reaction Time;
Volunteers;
Weights and Measures
- From:Korean Journal of Psychopharmacology
1998;9(2):119-130
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was done to compare the effects of nemonapride on cognitive and psychomotor performance and sedation with those of classical antipsychotics in normal adults. Single doses of three antipsychotics (chlorpromazine 50mg, haloperidol 2mg and nemonapride 3mg) and placebo were given to 8 healthy male volunteers at weekly intervals, in a double-blind Latin square design. All subjects completed a battery of cognitive and psychomotor pelformance tests (Critical Flicker Fusion Threshold : CFFT, Choice Reaction Time : CRT, Compensatory Tracking Test : CTT, Digit-Symbol Substitution Test DSST) and self-estimate for sedation using visual analog rating scales at pre-dose and 2, 4, 6, 8hr post-dose. The results were as follows : 1) Chlorpromazine 50mg significantly impaired CFFT, CRT, CTT and DSST compared to placebo and showed the most potent sedative effect among the test drugs. These effects occurred in almost all ranges of time points with peak effEct at 4hr post-dose. 2) Haloperidol 2 mg did not impair any cognitive or psychomotor performances. There was no sedative effect as well. 3) Nemo-napride 3 mg selectively impaired CFFT (at 2 and 6hr post-dose), total reaction time (at 4hr post-dose) of CRT and DSST (at 4 and 6hr post-dose). Sedative effect occurred more significantly than placebo at 4 and 6 hr post-dose. These results indicate that nemonapride 3mg seems to have the intermediate profiles between chlorpromazine 50mg and haloperidol 2mg in terms of cognitive and psychomotor effects as well as sedative effect. In addition, inspection of the results suggest that the cognitive and psychomotor effects could be secondary to sedative effect.
