Analysis of Biliary Stricture after ABO Incompatible Adult Living Donor Liver Transplantation.
10.4285/jkstn.2012.26.4.277
- Author:
Young In YOON
1
;
Gi Won SONG
;
Sung Gyu LEE
;
Shin HWANG
;
Chul Soo AHN
;
Ki Hun KIM
;
Deok Bog MOON
;
Tae Yong HA
;
Dong Hwan JUNG
;
Gil Chun PARK
;
Jung Man NAMGUNG
;
Yo Han PARK
;
Chun Soo PARK
;
Hyoung Woo PARK
;
Sung Hwa KANG
;
Bo Hyun JUNG
Author Information
1. Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. drsong71@hotmail.com
- Publication Type:Original Article
- Keywords:
Blood group incompatibility;
Bile duct stricture;
Living donor liver transplantation
- MeSH:
Adult;
Blood Group Incompatibility;
Constriction, Pathologic;
Graft Survival;
Humans;
Incidence;
Liver;
Liver Transplantation;
Living Donors;
Survival Rate;
Transplants
- From:The Journal of the Korean Society for Transplantation
2012;26(4):277-286
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Despite recent improvements in survival outcome after ABO incompatible (ABOi) adult living donor liver transplantation (ALDLT), concerns about the incidence of biliary stricture (BS) still exist. However, reports on the actual incidence of BS have been scarce. METHODS: From November 2008 to August 2011, 77 cases of ABOi ALDLTs have been performed. We compared patient and graft survival and BS-free survival rates (BSFSR) between these ABOi ALDLTs and 734 ABO compatible (ABOc) ALDLTs performed during the same period. We also analyzed characteristics of BS in ABOi ALDLT. RESULTS: There was one mortality (1.3%) and one re-transplantation (due to small-for-size graft syndrome) among 77 cases of ABOi ALDLTs. Overall, 1-, 2-, and 3-year patient survival rates were 94.8%, comparable to ABOc ALDLTs (93.7%, 90.1%, 90.1%, P=0.20). BS occurred in 11 (13.8%) ABOi ALDLT patients. There were no significant differences in 1-, 2-, and 3-year BSFSR between ABOi and ABOc ALDLT patients (87.5% vs. 88.1%, 83.4% vs. 87.5%, and 83.4% vs. 86.4%, P=0.55). Among 10 patients with BS, four patients showed diffuse multiple intrahepatic strictures, which were linked to the death of two patients. CONCLUSIONS: The survival outcome of ABOi ALDLT is comparable to ABOc ALDLT. The incidence of BS of ABOi ALDLT was not superior to that of ABOc ALDLT. However, ABO incompatibility is related to the development of diffuse multiple intrahepatic BSs (rarely seen in ABOc ALDLT) and can cause graft failure and patient death.
