Comparison of radical prostatectomy and external beam radiotherapy in high-risk prostate cancer
- Author:
Seok-Joo CHUN
1
;
Jin Ho KIM
;
Ja Hyeon KU
;
Cheol KWAK
;
Eun Sik LEE
;
Suzy KIM
Author Information
- Publication Type:Original Article
- From:Radiation Oncology Journal 2021;39(3):231-238
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:We evaluated clinical outcomes of high-risk prostate cancer patients receiving external beam radiotherapy (EBRT) or radical prostatectomy (RP).
Materials and Methods:Patients were classified as high-risk prostate cancer and received definitive treatment between 2005 and 2015. Patients with previous pelvic radiotherapy, positive lymph node or distant metastasis were excluded. The primary outcomes were prostate cancer-specific survival (PCSS) and distant metastasis-free survival (DMFS).
Results:Of 583 patients met the inclusion criteria (77 EBRT and 506 RP). The estimated 10-year PCSS was 97.0% in the RP and 95.9% in the EBRT (p = 0.770). No significant difference was seen in the DMFS (p = 0.540), whereas there was a trend in favor of RP over EBRT in overall survival (OS) (p = 0.068). Propensity score matching analysis with confounding variables was done, with 183 patients (66 EBRT and 117 RP) were included. No significant difference in DMFS, PCSS or OS was found.
Conclusion:Our data demonstrated similar oncologic PCSS, OS, and DMFS outcomes between EBRT and RP patients.
