Increasing Trend of Colorectal Cancer Incidence in Korea, 1999-2009.
- Author:
Aesun SHIN
1
;
Kyee Zu KIM
;
Kyu Won JUNG
;
Sohee PARK
;
Young Joo WON
;
Jeongseon KIM
;
Dae Yong KIM
;
Jae Hwan OH
Author Information
1. Molecular Epidemiology Branch, National Cancer Center, Goyang, Korea.
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Incidence;
Korea;
Trends
- MeSH:
Colon;
Colonic Neoplasms;
Colorectal Neoplasms;
Female;
Humans;
Incidence;
Korea;
Male;
Mass Screening;
Receptor, Insulin;
Rectal Neoplasms;
Rectum;
Risk Factors
- From:Cancer Research and Treatment
2012;44(4):219-226
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study was conducted in order to demonstrate changing trends in colorectal cancer incidence according to sex, age group, and anatomical location in the Korean population. MATERIALS AND METHODS: Data from the Korea Central Cancer Registry between 1999 and 2009 were analyzed. Annual percent changes (APCs) of sex- and age-specific incidence rates for cancer of the proximal colon (International Statistical Classification of Diseases and Related Health Problems, 10th revision [ICD-10] code C18.0-18.5), distal colon (C18.6-18.7), and rectum (C19-20), and male-to-female incidence rate ratios (IRR) were calculated. RESULTS: The age-standardized incidence rate (ASR) of colorectal cancer was 27 (per 100,000) in 1999 and increased to 50.2 in 2009 among men (APC, 6.6%). The ASR for women was 17.2 in 1999 and 26.9 in 2009 (APC, 5.1%). The rectum was the most common site of cancer among both men and women during 1999 and 2009. However, the distal colon had the highest APC (10.8% among men and 8.4% among women), followed by the proximal colon (7.9% among men and 6.6% among women), and rectum (5.2% among men and 2.4% among women). The proportion of rectal cancer decreased from 51.5% in 1999 to 47.1% in 2009 among men, and from 50.5% to 42.8% among women. An increase in the male-to-female IRR was observed for distal colon cancer and rectal cancer, whereas the IRR for proximal colon cancer was stable. CONCLUSION: The rapid increase in colorectal cancer incidence is mainly attributed to the increase in colon cancer, especially distal colon cancer, and may be explained by a transition of risk factors for subsites or by the effect of colorectal cancer screening.
