Calyxaprenols A-D, New Merohexaprenoid Metabolites from the Marine Sponge Calyx sp.
- Author:
Chang-Kwon KIM
1
;
Kirk R. GUSTAFSON
Author Information
- Publication Type:Original Article
- From:Natural Product Sciences 2020;26(4):303-310
- CountryRepublic of Korea
- Language:English
- Abstract: Four new merohexapenoids named calyxaprenols A-D (1 - 4), together with the known compound haliclotriol A (5), have been isolated from the marine sponge Calyx sp. which was collected from the southwest islands of Palau. Based on comprehensive spectroscopic analyses, calyxaprenols A (1) and B (2) were determined to be pentacyclic hexaprenoids that are appended to a glycolic acid-substituted phenol moiety, whereas calyxaprenols C (3) and D (4) possess a tricyclic hexaprenoid skeleton joined to a hydroquinone ring.Identification of new merohexaprenoids from a Calyx sponge expands the known taxonomic distribution of this sparsely distributed class of marine metabolites and increases the chemical diversity described for this genus of marine sponge.
