Molecular Networking-based De-replication Strategy Leads to the Isolation of a New Chromone from Pleosporales sp.
- Author:
Haeun KWON
1
;
Jun Gu KIM
;
Jeong-Joo OH
;
Jae-Jin KIM
;
Gyu-Hyeok KIM
;
Bang Yeon HWANG
;
Joung Han YIM
;
Dongho LEE
Author Information
- Publication Type:Original Article
- From:Natural Product Sciences 2020;26(4):340-344
- CountryRepublic of Korea
- Language:English
- Abstract: A new chromone analogue (1) was isolated from an EtOAc-extract of Pleosporales sp. culture medium, together with five known chromones (2 – 6). The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using NMR and MS spectroscopy, and the absolute configuration was established by the Mosher's method. All isolated compounds were evaluated for their inhibitory effects on lipopolysaccharide-induced nitirc oxide production in RAW 264.7 macrophages. Compound 1 showed marginal inhibitory activity with an IC50 value of 118.7 μM.
