Transgenic fluorescent zebrafish lines that have revolutionized biomedical research
10.1186/s42826-021-00103-2
- Author:
Chong Pyo CHOE
1
;
Seok-Yong CHOI
;
Yun KEE
;
Min Jung KIM
;
Seok-Hyung KIM
;
Yoonsung LEE
;
Hae-Chul PARK
;
Hyunju RO
Author Information
1. Division of Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea
- Publication Type:REVIEW
- From:Laboratory Animal Research
2021;37(3):156-184
- CountryRepublic of Korea
- Language:English
-
Abstract:
Since its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish lines expressing fluorescent proteins in a molecule, intracellular organelle, cell or tissue specific manner because they allow the visualization and tracking of molecules, intracellular organelles, cells or tissues of interest in real time and in vivo. In this review, we summarize representative transgenic fluorescent zebrafish lines that have revolutionized biomedical research on signal transduction, the craniofacial skeletal system, the hematopoietic system, the nervous system, the urogenital system, the digestive system and intracellular organelles.
