Variation in Serum Creatinine Level Is Correlated to Risk of Type 2 Diabetes.
10.3803/EnM.2013.28.3.207
- Author:
Jun Sung MOON
1
;
Ji Eun LEE
;
Ji Sung YOON
Author Information
1. Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. jsyoon9@ynu.ac.kr
- Publication Type:Original Article
- Keywords:
Diabetes mellitus;
Risk factors;
Creatinine;
Muscle mass
- MeSH:
Adipose Tissue;
Blood Pressure;
Body Composition;
Body Mass Index;
Cholesterol;
Cholesterol, HDL;
Creatinine;
Diabetes Mellitus;
Electric Impedance;
Fasting;
Follow-Up Studies;
gamma-Glutamyltransferase;
Glomerular Filtration Rate;
Glucose;
Hemoglobins;
Hypoglycemic Agents;
Insulin;
Lipoproteins;
Muscle, Skeletal;
Muscles;
Plasma;
Risk Factors
- From:Endocrinology and Metabolism
2013;28(3):207-213
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Skeletal muscle is well established as a major target organ of insulin action, and is associated with the pathogenesis of type 2 diabetes. Therefore, we attempted to determine whether a variation in serum creatinine is related to the development of type 2 diabetes and other risk factors for diabetes. METHODS: A total of 2,676 nondiabetic subjects with stable and normal renal function (estimated glomerular filtration rate >60 mL/min/1.73 m2) were followed up for approximately 4.5 years. New onset diabetes was defined as fasting plasma glucose (FPG) > or =7.0 mmol/L, glycated hemoglobin (HbA1c) > or =6.5%, or subjects taking antidiabetic agents. Variation of serum creatinine (DeltaCre) was defined as a difference between follow-up and baseline creatinine. In subgroup analysis, body composition was examined by bioelectric impedance analysis method. RESULTS: A total of 106 subjects were diagnosed with new-onset diabetes during the follow-up period. Baseline serum creatinine was not different between the new-onset diabetes and no diabetes groups. Negative DeltaCre (DeltaCre <0) showed an association with increased risk of type 2 diabetes after adjusting for age, sex, body mass index, systolic blood pressure, FPG, HbA1c, triglyceride, high density lipoprotein cholesterol, and gamma-glutamyl transpeptidase (odds ratio, 1.885; 95% confidence interval, 1.127 to 3.153). Serum creatinine level demonstrated positive correlation with muscle mass and negative correlation with percentage of body fat in body composition analysis. CONCLUSION: Serum creatinine reflected body muscle mass and the decrease of serum creatinine might be regarded as a risk factor for type 2 diabetes.
