Utility of Next-Generation Sequencing for Deciphering Intratumor Heterogeneity in Prostate Cancer
10.22465/kjuo.2021.19.2.101
- Author:
Je-Gun JOUNG
1
;
Joo-Young PARK
;
So-Yun YANG
;
Jeongyun JEONG
Author Information
1. Samsung Genome Institute, Samsung Medical Center, Seoul, Korea
- Publication Type:Review Article
- From:Korean Journal of Urological Oncology
2021;19(2):101-108
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Prostate cancer has long been considered a disease with a heterogeneous phenotype. The intratumor heterogeneity (ITH) may affect diverse phenotypes such as treatment response, drug resistance, and overall clinical outcomes. Despite technical advances over the past decade, we have an incomplete understanding of the extent and effects of ITH in prostate cancer progression. We present here a comprehensive review of the various studies dealing with ITH in prostate cancer. We discuss the advanced next-generation sequencing analyses including single cell sequencing and circulating cell-free DNA sequencing that have the impact of heterogeneity on clinical decision making.
