Diffusion Tensor Imaging Changes Correlate with Clinical Progression in Vascular Mild Cognitive Impairment and Vascular Dementia of Subcortical Type.
10.12779/dnd.2013.12.3.61
- Author:
Na Young RYOO
1
;
Byung Nam YOON
;
Cindy W YOON
;
Jong Hyeon AHN
;
Jun Yong CHOI
;
Myung Kwan LIM
;
Hunki KWON
;
Jun Sung PARK
;
Jong Min LEE
;
Seong Hye CHOI
Author Information
1. Department of Neurology, Inha University School of Medicine, Incheon, Korea. seonghye@inha.ac.kr
- Publication Type:Original Article
- Keywords:
Subcortical vascular dementia;
Small vessel disease;
Diffusion tensor imaging
- MeSH:
Anisotropy;
Brain;
Cerebral Small Vessel Diseases;
Cross-Sectional Studies;
Dementia;
Dementia, Vascular;
Depression;
Diffusion;
Diffusion Tensor Imaging;
Executive Function;
Glycosaminoglycans;
Humans;
Mild Cognitive Impairment;
Neuropsychological Tests;
Neuropsychology;
Stroke, Lacunar
- From:Dementia and Neurocognitive Disorders
2013;12(3):61-71
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Cerebral small vessel disease (SVD) induces vascular cognitive impairment (VCI) such as subcortical vascular dementia (SVaD) and subcortical vascular mild cognitive impairment (svMCI). We compared MRI parameters between SVaD and svMCI and determined which MRI parameters best correlated with cognitive function and disability on cross-sectional and longitudinal analyses within them. METHODS: Twenty-four patients with SVaD and twelve with svMCI were recruited. They underwent multimodal MRIs including fluid-attenuated inversion recovery lesion load, lacunar infarct number, and fractional anisotropy (FA) and mean diffusivity (MD) from diffusion tensor imaging (DTI), neuropsychological testing, Sum of Boxes of Clinical Dementia Rating Scale (CDR-SB), Barthel Index, and the Korean version of a Geriatric Depression Scale (GDS-K). Seventeen patients were retested after 20 months for a brain MRI and clinical evaluation. RESULTS: There were significant differences in average MD and peak height of MD histograms within normal-appearing brain tissue (NABT) between SVaD and svMCI patients. In the cross-sectional analysis, average MD within NABT significantly correlated with the composite neuropsychology score (r=-0.80, p<0.001), the composite executive function score (r=-0.67, p< 0.001), and the CDR-SB (r=0.54, p=0.001), and the Barthel Index correlated with peak heights of the MD histograms (r=0.37, p=0.03) in NABT. Changes of CDR-SB was associated with changes of average MD within WMH (r=0.57, p=0.02), and changes of GDS-K was associated with changes of WMH volume (r=0.51, p=0.04) on a longitudinal scale. CONCLUSIONS: DTI parameters in NABT correlated with cognitive impairment and disability in VCI associated with SVD. Clinical progression of SVD was associated with some increment of WML volume and ultrastructural changes in WMH.
