Epigenetic Regulation in the Brain after Spinal Cord Injury : A Comparative Study.
10.3340/jkns.2013.53.6.337
- Author:
Bit Na Ri PARK
1
;
Seok Won KIM
;
Sung Rae CHO
;
Ji Yong LEE
;
Young Hee LEE
;
Sung Hoon KIM
Author Information
1. Department of Rehabilitation Medicine, Wonju Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea. kimrehab@yonsei.ac.kr
- Publication Type:Comparative Study ; Original Article
- Keywords:
Spinal cord injury;
Regulators;
Brain;
Brain derived neurotrophic factor;
Epigenetic
- MeSH:
Animals;
Brain;
Brain-Derived Neurotrophic Factor;
Epigenomics;
Female;
Glial Cell Line-Derived Neurotrophic Factor;
Histone Deacetylases;
Humans;
Mice;
Motor Cortex;
Nerve Growth Factor;
Neurons;
Spinal Cord;
Spinal Cord Injuries;
Up-Regulation
- From:Journal of Korean Neurosurgical Society
2013;53(6):337-341
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: After spinal cord injury (SCI), functional and structural reorganization occurs at multiple levels of brain including motor cortex. However, the underlying mechanism still remains unclear. The current study was performed to investigate the alterations in the expression of the main regulators of neuronal development, survival and death, in the brain following thoracic contusive SCI in a mouse model. METHODS: Eight-week-old female imprinting control region mice (n=60; 30-35 g) were used in this study. We analyzed the expression levels of regulators such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and histone deacetylase (HDAC) 1 in the brain following thoracic contusive SCI. RESULTS: The expression of BDNF levels were elevated significantly compared with control group at 2 weeks after injury (p<0.05). The expression of NGF levels were elevated at 2, 4 weeks compared with control group, but these difference were not significant (p>0.05). The GDNF levels were elevated at 2 week compared with control group, but these differences were not significant (p>0.05). The difference of HDAC1 levels were not significant at 2, 4 and 8 weeks compared with control group (p>0.05). CONCLUSION: These results demonstrate that the upregulation of BDNF may play on important role in brain reorganization after SCI.
