Clinically Significant Monocyte Biomarker for Differential Diagnosis of COVID-19 Pneumonia in the Emergency Department
- Author:
Hyo-Won KIM
1
;
Jae Cheon JEON
;
Woo Ik CHOI
;
Ji Yeon LEE
;
Yong Sik KWON
;
Mi Jin LEE
;
Jae Wan CHO
;
Gyunmoo KIM
;
You Ho MUN
;
Sang-Hun LEE
Author Information
- Publication Type:Original Article
- From:Keimyung Medical Journal 2021;40(1):26-31
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objectives:To determine basic patient characteristics and biomarkers to help in the early diagnosis of Coronavirus disease 2019 (COVID-19) pneumonia in patients with pneumonia who visited the emergency department (ED).
Methods:This retrospective study evaluated patients diagnosed with community-acquired pneumonia (CAP) or COVID-19 pneumonia in ED at four tertiary medical centers between February 1 and March 31, 2020. Parameters related to the differential diagnosis between CAP and COVID-19 were investigated. Clinical characteristics and laboratory results of biomarkers were analyzed.
Results:In total, 81 patients presented to the ED with COVID-19 pneumonia. Multivariate logistic regression analysis showed that monocyte count [odds ratio (OR): 0.996; 95% confidence interval (CI): 0.994–0.999] and pneumonia severity index (PSI) [OR: 1.025; 95% CI: 1.002–1.049] were associated with diagnosis of COVID-19 pneumonia. The area under the curve comprising the combination of monocyte and PSI was 0.789.
Conclusion:Differential diagnosis of COVID-19 pneumonia from pneumonia patients who visited the emergency room can be made by monocyte count and PSI score.
