Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls
- Author:
Hitoshi MIZUGUCHI
1
;
Keiichiro KIZAKI
;
Atsushi KIMURA
;
Shiro KUSHIBIKI
;
Kentaro IKUTA
;
Yo-Han KIM
;
Shigeru SATO
Author Information
- Publication Type:Rapid Communication
- From:Journal of Veterinary Science 2021;22(3):e34-
- CountryRepublic of Korea
- Language:English
- Abstract: Anti-lipopolysaccharide (LPS) antibody administration has the potential benefits of neutralizing and consequently controlling rumen-derived LPS during subacute ruminal acidosis. Four Holstein bulls were used in this crossover study with a 2-week wash-out period. Anti-LPS antibody (0 or 4 g) was administered once daily for 14 days. Significantly lower ruminal LPS and higher 1-h mean ruminal pH were identified in the 4 g group. However, blood metabolites, acute-phase proteins, cytokines, and hepatic transcriptomes were not different between the two groups. Therefore, anti-LPS antibody administration mitigated ruminal LPS release and pH depression without accompanying responses in acute-phase inflammation or hepatic transcriptomic expression.
