Common interleukin 10 polymorphism associated with decreased risk of tuberculosis.
- Author:
Hyoung Doo SHIN
1
;
Byung Lae PARK
;
Lyoung Hyo KIM
;
Hyun Sub CHEONG
;
In Hee LEE
;
Seung Kyu PARK
Author Information
1. Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Jongno 4-ga, Jongno-gu, Seoul, Korea. pulmo116@empal.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
IL10;
polymorphism;
tuberculosis
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
*Genetic Predisposition to Disease;
Genotype;
Humans;
Interleukin-10/*genetics;
Korea;
Middle Aged;
Polymorphism, Single Nucleotide;
Research Support, Non-U.S. Gov't;
Risk;
Tuberculosis, Pulmonary/*genetics
- From:Experimental & Molecular Medicine
2005;37(2):128-132
- CountryRepublic of Korea
- Language:English
-
Abstract:
Interleukin 10 (IL10) is a powerful TH2-cell cytokine that inhibits lymphocyte replication and secretion of inflammatory cytokines. The genetic associations of polymorphisms in IL10 with clinical manifestations of tuberculosis (TB) were examined in a large number of patients with clinical TB infection (n=459) and normal controls (n=871). One common promoter SNP (IL10 -592 A>C) was found to be significantly associated with decreased risk of TB manifestation. The frequency of the "C"-bearing genotype was higher in normal controls than in patients with clinical TB infection (P=0.005, OR=0.69). A summary of the genetic effect of IL10 -1082 A>G, the other nearby promoter SNP, in other ethnic groups is also presented.
