Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro.
- Author:
Jong Moon HUR
1
;
Joong Sup SHIM
;
Hye Jin JUNG
;
Ho Jeong KWON
Author Information
1. Chemical Genomics National Research Laboratory, Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, 98 Gunja-dong, Gwangjin-gu, Seoul, Korea. kwonhj@sejong.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
abietane;
angiogenesis;
cryptotanshinone;
Salvia miltiorrhiza;
tanshinone
- MeSH:
Angiogenesis Inhibitors/chemistry/isolation & purification/*pharmacology;
Animals;
Cattle;
Cell Movement/drug effects;
Cell Proliferation/drug effects;
Cells, Cultured;
Drugs, Chinese Herbal/chemistry/isolation & purification/pharmacology;
Endothelial Cells/drug effects/physiology;
Fibroblast Growth Factor 2/pharmacology;
Humans;
Neovascularization, Physiologic/drug effects;
Phenanthrenes/chemistry/isolation & purification/*pharmacology;
Plant Roots/chemistry;
Research Support, Non-U.S. Gov't;
Salvia miltiorrhiza/*chemistry
- From:Experimental & Molecular Medicine
2005;37(2):133-137
- CountryRepublic of Korea
- Language:English
-
Abstract:
In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity. Tanshinone IIA, another tanshinone isolated from S. miltiorrhiza, which is structurally very similar to cryptotanshinone except C-15 position of dihydrofuran ring does not inhibit angiogenesis induced by bFGF. These results demonstrate that cryptotanshinone is a new anti-angiogenic agent and double bond at C-15 position of the dihydrofuran ring plays a crucial role in the activity.
