Herpes Simplex Virus and Varicella Zoster Virus Infections in Adult Kidney Transplant Recipients: Incidence and Risk Factor Analysis.
- Author:
Sulra LEE
1
;
Juyoung MOON
;
Kyunghwan JUNG
;
Sangho LEE
;
Chunkyu LIM
;
Taewon LEE
Author Information
1. Division of Nephrology, Department of Internal Medicine Kyunghee University College of Medicine, Seoul Korea. lsr0101@freechal.com
- Publication Type:Original Article
- Keywords:
Kidney transplantation;
Herpes simplex virus;
Varicella zoster virus
- MeSH:
Adult;
Chickenpox;
Herpes Simplex;
Herpesvirus 3, Human;
Humans;
Immunosuppression;
Incidence;
Kidney;
Kidney Transplantation;
Methylmethacrylates;
Polystyrenes;
Prevalence;
Rejection (Psychology);
Risk Factors;
Simplexvirus;
Transplants
- From:Korean Journal of Nephrology
2009;28(2):135-141
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE:Enhanced immunosuppression for preventing acute rejection, But infection is an inevitable complication. This study was performed to evaluate the risk factors of herpes simplex virus (HSV) and varicella zoster virus (VZV) infection which are frequent and serious complication of renal transplant recipients. METHOD:We evaluated the incidence and risk factors for post-transplant HSV and VZV infection in three hundred and twenty three adult renal transplant recipients. RESULTS:The averaged period of infection was 37.8 months and 42% of infection occurred within six month after transplantation. Prevalence of HSV and VZV infection in diabetes patients are higher than that of non-diabetes patients (p=0.01). The other factors such as age, sex, acute rejection and immunosuppressive regimens, antibody induction didnt affect HSV and VZV infections in renal transplant recipients. CONCLUSION:As diabetic condition suggested more susceptibility to HSV and VZV infections, it is necessary to evaluate the possible occurrence of HSV and VZV infections carefully in transplant recipients with diabetes.
