Clinical and Genetic Risk Factors Associated With the Presence of Lupus Nephritis
10.4078/jrd.2021.28.3.150
- Author:
Jung-Min SHIN
1
;
Dam KIM
;
Young-Chang KWON
;
Ga-Young AHN
;
Jiyoung LEE
;
Youngho PARK
;
Yeon-Kyung LEE
;
Tae-Han LEE
;
Dae Jin PARK
;
Yeo-Jin SONG
;
Eunji HA
;
Kwangwoo KIM
;
So-Young BANG
;
Chan-Bum CHOI
;
Hye-Soon LEE
;
Sang-Cheol BAE
Author Information
1. Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea
- Publication Type:Original Article
- From:Journal of Rheumatic Diseases
2021;28(3):150-158
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:To elucidate whether clinical features and the weighted genetic risk score (wGRS) were associated with the presence of lupus nephritis (LN).
Methods:We retrospectively divided patients with systemic lupus erythematosus (SLE, n=1,078) into biopsy-proven LN (n=507) and non-LN groups (non-LN, n=571). Baseline clinical features, serologic markers, and the wGRS were collected. The wGRS was calculated from 112 non-human leukocyte antigen (non-HLA) loci and HLA-DRβ1 amino acid haplotypes for SLE. Associations among clinical features, wGRS, and the presence of LN were identified.
Results:In the multivariate analysis, patients with LN were younger at diagnosis (odds ratio [OR]=0.97, p＜0.001), had more pleuritis (OR=2.44, p＜0.001) and pericarditis (OR=1.62, p=0.029), had a higher detection rate of anti-double stranded deoxyribonucleic acid (anti-dsDNA antibodies, OR=2.22, p＜0.001), anti-Smith antibodies (anti-Sm antibodies, OR=1.70, p=0.002), low level of complement (OR=1.37, p=0.043) and absence of antiphospholipid antibodies (aPL antibodies, OR=1.60, p=0.002), and had higher wGRS (OR=1.16, p=0.012). Mediation analysis suggested that anti-Sm antibodies and low complement could be mediators in the relationship between high wGRS and the presence of LN.
Conclusion:Onset age, pleuritis, pericarditis, several serologic markers, and wGRS were associated with the presence of LN. Anti-Sm antibodies and low complement appeared to mediate the indirect relationship between wGRS and the presence of LN.
