Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life
- Author:
Sayuri YAMAMOTO
1
;
Yurika KAWAMURA
;
Kazuhiro YAMAMOTO
;
Yoshiharu YAMAGUCHI
;
Yasuhiro TAMURA
;
Shinya IZAWA
;
Hiroaki NAKAGAWA
;
Yoshinori WAKITA
;
Yasutaka HIJIKATA
;
Masahide EBI
;
Yasushi FUNAKI
;
Wataru OHASHI
;
Naotaka OGASAWARA
;
Makoto SASAKI
;
Masato MAEKAWA
;
Kunio KASUGAI
Author Information
- Publication Type:Original Article
- From:Journal of Neurogastroenterology and Motility 2021;27(4):602-611
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background/Aims:Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population.
Methods:This cross-sectional internet-based survey included 3000 subjects with constipation, classified according to sleep status (good/poor).Primary endpoints were Bristol stool form scale (BSFS) score and correlations between sleep disorder criteria of the Pittsburgh Sleep Quality Index (PSQI) and sleep status (good/poor sleep). Secondary endpoints included correlations between quality of life (QOL) and mood, medical, lifestyle, and sleep factors.
Results:The proportion of participants with BSFS category 4 (normal stool) was significantly higher in the good sleep group (P < 0.001). Sleep disturbance (P < 0.05), sleep quality, and duration, use of hypnotic medication, and daytime dysfunction of PSQI (all P < 0.001) significantly correlated with poor sleep. In the poor sleep group, QOL was significantly worse and anxiety and depression levels were significantly higher (allP < 0.001) compared with the good sleep group. Anemia and smoking (both P < 0.05), recent body weight increases, and poor eating habits (all P < 0.001) were significantly higher in the poor sleep group. Male sex, onset associated with change in frequency of stools, sensation of incomplete evacuation for at least 25% of defecations, and manual maneuvers to facilitate at least 25% of defecations correlated with poor sleep.
Conclusions:Subjects with constipation and poor sleep experienced severe symptoms and had poor QOL. These data support the need for a multifocal treatment approach, including lifestyle advice and pharmacotherapy.
