A Case of Malignant Eccrine Poronta.
- Author:
Joung Soo KIM
1
;
Young Suck RO
;
Chan Kum PARK
Author Information
1. Department of Dermatology, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Malignailt eccrine poroma
- MeSH:
Biopsy;
Eccrine Porocarcinoma;
Keratins;
Lower Extremity;
Lymph Nodes;
Mucin-1;
Neoplasm Metastasis;
Poroma;
Sweat Glands;
Vacuoles
- From:Korean Journal of Dermatology
1998;36(4):717-721
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Malignant eccrine poroma is a rare malignant tumor arising from the intraepidermal ductal portion of the eccrine sweat gland, which develops either spontaneously or from a long-standing benign eccrine poroma. It usually affects older people and is located most commonly on the lower extremities. We describe a typical case of malignant eccrine poroma developing from benign eccrine poroma, which had been present for 10 years or more, with subsequent regional lymph node metastasis. A biopsy specimen revealed many well-defined intraepidermal nests of poroma cells with dermal invasion and lymphatic involvement of tumor cells. Immunohistochemical studies showed staining with cocktail cytokeratin, carcino-embryonic antigen, epithelial membrane antigen in intracellular vacuoles of tumor cells and early embryonic stages of eccrine duct formation. Local excision with postoperative adjuvant radiation therapy showed only a temporary response.
