Conservation of matrix protein genes in rabies viruses circulating in South Korea since 1999.
10.14405/kjvr.2017.57.4.249
- Author:
Young Ae LEE
1
;
Ha Hyun KIM
;
Dong Kun YANG
;
In Soo CHO
Author Information
1. Viral Disease Research Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affair, Gimcheon 39660, Korea. yangdk@korea.go.kr
- Publication Type:Brief Communication
- Keywords:
genetic distance;
phylogeny;
rabies virus;
viral matrix proteins
- MeSH:
Amino Acid Substitution;
Animals;
China;
Korea*;
Phylogeny;
Rabies virus*;
Rabies*;
Viral Matrix Proteins;
Virulence
- From:Korean Journal of Veterinary Research
2017;57(4):249-252
- CountryRepublic of Korea
- Language:English
-
Abstract:
Rabies virus (RABV) causes a neurological disease in warm-blooded animals that is nearly always fatal. In this study, we analyzed the matrix (M) genes in 10 Korean street RABV strains isolated from two Provinces during 2011–2013. The M genes in these 10 Korean strains were highly conserved during 1999–2013. Phylogenetic analysis revealed they were closely related to the M genes of RABVs isolated in northeastern China. Specific amino acid substitutions were identified in the KRVB1206, KRVF1301, and BV9901PJ strains. However, functional domains, including those involved in virus production and pathogenicity, were conserved in all 10 strains.
