Elevated Ki-67 (MIB-1) Expression as an Independent Predictor for Poor Prognosis After Radical Cystectomy for Bladder Cancer.
10.22465/kjuo.2017.15.3.152
- Author:
Hakmin LEE
1
;
Dong Hwan LEE
;
Younsoo CHUNG
;
Ngoc Ha NGUYEN
;
Jong Jin OH
;
Sangchul LEE
;
Sang Eun LEE
;
Sung Kyu HONG
;
Seok Soo BYUN
Author Information
1. Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea. 65828@snubh.org
- Publication Type:Original Article
- Keywords:
Bladder cancer;
Cystectomy;
Ki-67;
Survival;
Recurrence
- MeSH:
Cystectomy*;
Humans;
Logistic Models;
Mortality;
Prognosis*;
Proportional Hazards Models;
Prospective Studies;
Recurrence;
Retrospective Studies;
Urinary Bladder Neoplasms*;
Urinary Bladder*
- From:Korean Journal of Urological Oncology
2017;15(3):152-157
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We tried to investigate the clinical impact of Ki-67 (MIB-1) expression on the oncological and survival outcomes in patients with bladder cancer (BCa) after the radical cystectomy. MATERIALS AND METHODS: We retrospectively analyzed the data of 230 patients who were treated by radical cystectomy for BCa. Multivariate Cox-proportional hazards models and logistic regression tests were performed to evaluate the prognostic value of each variable. RESULTS: The patients with positive Ki-67 expression showed significant worse clinical characteristics and pathologic outcomes than negative Ki-67 group. Furthermore, the patients with Ki-67 expression showed significant worse recurrence (p=0.018) and cancer-specific mortality free survival (p=0.019) than negative Ki-67 group. The overall survival was also revealed to be inferior in Ki-67 positive group than Ki-67 negative group but the statistical significance was marginal (p=0.062). Subsequent multivariate Cox analyses showed that Ki-67 was independent predictor for disease recurrence after surgery (hazard ratio, 3.142; 95% CI, 1.287–7.671; p=0.012). CONCLUSIONS: In our study, high Ki-67 expression was significantly related with worse clinical outcomes after radical cystectomy in the patients with BCa. Further prospective and basic researches are needed to validate the true prognostic value of Ki-67.
