Smoking History and Clinical Features of Cluster Headache:Results from the Korean Cluster Headache Registry
10.3988/jcn.2021.17.2.229
- Author:
Pil-Wook CHUNG
1
;
Byung-Su KIM
;
Jeong-Wook PARK
;
Jong-Hee SOHN
;
Mi Ji LEE
;
Byung-Kun KIM
;
Min Kyung CHU
;
Jin-Young AHN
;
Yun-Ju CHOI
;
Tae-Jin SONG
;
Dae-Woong BAE
;
Daeyoung KIM
;
Jae-Moon KIM
;
Soo-Kyoung KIM
;
Kwang-Yeol PARK
;
Jae Myun CHUNG
;
Heui-Soo MOON
;
Kyungmi OH
;
Chin-Sang CHUNG
;
Soo-Jin CHO
Author Information
1. Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
- Publication Type:ORIGINAL ARTICLE
- From:Journal of Clinical Neurology
2021;17(2):229-235
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:and Purpose Epidemiologic data suggest that cluster headache (CH) is significantly associated with cigarette smoking. The aim of this study was to determine differences in features between patients with a smoking history and those who are never-smokers, using data from a prospective multicenter registry.
Methods:Data used in this study were obtained from the Korean Cluster Headache Registry that collected data from consecutive patients diagnosed with CH. We compared clinical and demographic features between ever-smokers (current or former smokers) and never-smokers.
Results:This study enrolled 250 patients who were diagnosed with CH, of which 152 (60.8%) were ever-smokers and 98 (39.2%) were never-smokers. The age at CH onset was significantly lower in the never-smoker group than in the ever-smoker group [27.1±12.9 years vs. 30.6± 10.9 years (mean±standard deviation), p=0.024]. Seasonal rhythmicity (58.1% vs. 44.7%, p= 0.038) and triptan responsiveness (100% vs. 85.1%, p=0.001) were higher in never-smokers, while other clinical features such as pain severity, duration, attack frequency, and associated autonomic symptoms did not differ significantly between the groups. The male-to-female ratio was markedly higher in ever-smokers (29.4:1) than in never-smokers (1.7:1).
Conclusions:Most of the clinical features did not differ significantly between patients with a smoking history and never-smokers. However, the age at CH onset, sex ratio, and seasonal rhythmicity were significantly associated with smoking history.
