Airway Reactivity to Bronchoconstrictor and Bronchodilator: Assessment Using Thin-Section and Volumetric Three-Dimensional CT.
- Author:
Boo Kyung HAN
1
;
Jung Gi IM
;
Hak Soo KIM
;
Jin Mo KOO
;
Hong Dae KI
;
Kyung Mo YEON
;
Hong Dae KIM
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Bronchi, CT; Lung, CT; Lung, effects of drugs on CT, three-dimensional
- MeSH: Albuterol/pharmacology; Animal; Bronchoconstriction/*physiology; Bronchoconstrictor Agents/*pharmacology; Bronchodilator Agents/*pharmacology; Dogs; *Imaging, Three-Dimensional; Methacholine Chloride/pharmacology; Tomography, X-Ray Computed/*methods
- From:Korean Journal of Radiology 2000;1(3):127-134
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To determine the extent to which thin-section and volumetric three-dimensional CT can depict airway reactivity to bronchostimulator, and to assess the effect of different airway sizes on the degree of reactivity. MATERIALS AND METHODS: In eight dogs, thin-section CT scans were obtained before and after the administration of methacholine and ventolin. Cross-sectional areas of bronchi at multiple levels, as shown by axial CT, proximal airway volume as revealed by three-dimensional imaging, and peak airway pressure were mea-sured. The significance of airway change induced by methacholine and ventolin, expressed by percentage changes in cross-sectional area, proximal airway volume, and peak airway pressure was statistically evaluated, as was correlation between the degree of airway reactivity and the area of airways. RESULTS: Cross-sectional areas of the bronchi decreased significantly after the administration of methacholine, and scans obtained after a delay of 5 minutes showed that normalization was insufficient. Ventolin induced a significant increase in cross-sectional areas and an increase in proximal airway volume, while the effect of methacholine on the latter was the opposite. Peak airway pres-sure increased after the administration of methacholine, and after a 5-minute delay its level was near that of the control state. Ventolin, however, induced no significant decrease. The degree of airway reactivity did not correlate with airway size. CONCLUSION: Thin-section and volumetric spiral CT with three-dimensional reconstruction can demonstrate airway reactivity to bronchostimulator. The degree of reactivity did not correlate with airway size.
