Specific Bioactive Collagen Peptides in Osteopenia and Osteoporosis: Long-Term Observation in Postmenopausal Women
10.11005/jbm.2021.28.3.207
- Author:
Denise ZDZIEBLIK
1
;
Steffen OESSER
;
Daniel KÖNIG
Author Information
1. CRI, Collagen Research Institute, Kiel, Germany
- Publication Type:Original Article
- From:Journal of Bone Metabolism
2021;28(3):207-213
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:The effects of specific collagen peptides on bone mineral density (BMD) in subjects with osteoporosis or osteopenia have already been investigated in 131 postmenopausal women in a randomized controlled trial. The purpose of this follow-up observation was to determine the longer-term effects of the same specific bioactive collagen peptides after a total intervention time of 4 years.
Methods:In this open-label follow-up observation, 31 postmenopausal women with reduced BMD (initial T-score lower than−1 of either the femoral neck or the lumbar spine) completed the follow-up. BMD was measured via dual energy X-ray absorptiometry. Absolute changes in BMD and T-scores in the spine and femoral neck were assessed. The number of fractures was also recorded. All participants received specific bioactive collagen peptides.
Results:Supplementation with bioactive collagen peptides during follow-up led to a clinically relevant increase in BMD in the spine. These findings were consistent with the results for the femoral neck.
Conclusions:Long-term supplementation with specific bioactive collagen peptides appears to be effective in counteracting losses in BMD. Moreover, significant increases in BMD could contribute to improved bone stability.
