Myelodysplastic Syndrome with Delayed Maturation of Reticulocytes: A Report of Three Cases.
- Author:
Sung Eun YANG
1
;
Joon Seok PARK
;
Eul Zu SEO
;
Hyun Sook CHI
Author Information
1. Department of Clinical Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
- Publication Type:In Vitro ; Case Report
- Keywords:
Myelodysplastic syndrome;
Reticulocytosis;
In vitro reticulocyte survival study
- MeSH:
Anemia;
Diagnosis, Differential;
Humans;
Myelodysplastic Syndromes*;
Reticulocyte Count;
Reticulocytes*;
Reticulocytosis
- From:Korean Journal of Clinical Pathology
1998;18(2):126-129
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anemia in myelodysplastic syndrome (MDS) is accompanied by reticulocytopenia in most patients. Reticulocytosis, when present, is generally less than appropriate to the degree of anemia and rarely exceeds 10%. In this report, three patients with MDS with persistent reticulocytosis are presented. In vitro reticulocyte survival studies have suggested that the reticulocytosis was caused by delay in maturation of the reticulocytes. Anemia with reticulocytosis, mimicking hemolytic disease, may be an unusual presentation of myelodysplastic syndrome, but, we emphasize that MDS should be included in the differential diagnosis of every patient presenting with anemia and high reticulocyte count. In vitro reticulotye survival study is easy to assess and valuable to diagnose this disease entity.
