Physiological Role of Vasoactive Intestinal Polypeptide on Penile Erection in Rats.
- Author:
Ki Hak MUN
1
;
Jun Kyu SUH
Author Information
1. Department of Urology, Yeungnan University, College of Medicine, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Impotence;
VIP;
in-vivo
- MeSH:
Animals;
Diagnosis;
Erectile Dysfunction;
Male;
Neurotransmitter Agents;
Penile Erection*;
Rats*;
Vasoactive Intestinal Peptide*
- From:Korean Journal of Urology
1994;35(6):592-598
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Vasoactive intestinal polypeptide (VIP) has a vasodilatory effect as a non-adrenergic, non-cholinergic neurotransmitter. The role of VIP on penile erection has been controversial. This study was undertaken to elucidate the effect of VIP on penile erection in-vivo and to predict whether this drug can be clinically applied to the diagnosis and/or treatment of impotence. The results are as follows. Intracavernosal injection of VIP alone (0.000000001to 0.00001M, n=10) did not show any increase in basal ICP Pretreatment of VIP (0.000005M, 0.00001M, n=7) enhanced partial erection induced by electric intensity with suboptimal level(frequency; 1 Hz, intensity; 1.2-2.0 volt, pulse duration, 1 msec.) (p<0.05)Intracavernosal injection of VIP-antagonist (0.000000001 to 0.00001M,n=7) was found to suppress the full erection induced by the optimal electric stimulation(frequency; 1 Hz, intensity; 3-4 volt, pulse duration; 1 msec.) in dose dependent manner (p<0.05). These results suggest that VIP may induce penile erection in rat through its receptor on corpus cavernosum, although it requires the cooperative action of other neurotransmitter(s).
