Grading of Superficial Bladder Cancer by Mitotic Indices.
- Author:
Chang Kyu LEE
1
;
Seong CHOI
;
Jong Chul KIM
;
Hyun Yul RHEW
Author Information
1. Department of Urology, Kosin University, College of Medicine, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Superficial bladder cancer;
Mitotic indices
- MeSH:
Classification;
Follow-Up Studies;
Humans;
Mitotic Index*;
Multivariate Analysis;
Recurrence;
Urinary Bladder Neoplasms*;
Urinary Bladder*
- From:Korean Journal of Urology
1994;35(6):605-613
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The relationship between the prognostic factors and recurrence was investigated in the followup study of patients with 51 superficial (stage Ta to T1) transitional cell bladder carcinomas for more than 3 years. WHO grade, modified Bergkvist grade and number of tumor were related to mitotic indices( p <0.05), but size of tumor was related to MAI only(p<0.05) In univariate analysis of prognostic factors, mitotic indices, number of tumor and posterior wall involvement were related to 3-year recurrence(p < 0.05). In multivariate analysis of prognostic factors, which were significantly related in univariate analysis, VCM and posterior wall involvement were related to 3-year recurrence and their hazard ratios were 9.33 times and 6.16 times In recurrence-free survival curve of prognostic factors, mitotic indices, number of tumor and posterior wall involvement were related (p <0.05). In classifying WHO grade 2 according to modified Bergkvist grade and mitotic indices, they were related to recurrence (p <0.05). The results show that superficial transitional cell bladder carcinomas can be efficiently categorized into prognostic groups by mitotic indices and the results provide a new classification system for superficial transitional cell bladder carcinomas.
