Dengue Virus is Hyperendemic in Nigeria from 2009 to 2020: A Contemporary Systematic Review
- Author:
Anthony Uchenna EMERIBE
1
;
Idris Nasir ABDULLAHI
;
Idongesit Kokoabasi ISONG
;
Anthony Ogbonna EMERIBE
;
Justin Onyebuchi NWOFE
;
Buhari Isa SHUAIB
;
Abubakar Muhammad GWARZO
;
Yahaya USMAN
;
Madjid SADI
;
Chikodi Modesta UMEOZURU
;
Amos DANGANA
;
Bibiana Nonye EGENTI
;
Mala Alhaji Baba MALLAM
;
Abigail Uchenna EMELONYE
;
Maijiddah Saidu AMINU
;
Hadiza YAHAYA
;
Silifat OYEWUSI
Author Information
- Publication Type:Original Article
- From:Infection and Chemotherapy 2021;53(2):284-299
- CountryRepublic of Korea
- Language:English
-
Abstract:
Materials and methods:Twenty-one studies out of 2,215 available articles were eligible and included for this systematic review. Relevant articles were searched, screened and included in this study according to the Preferred Reporting Items for Systematic reviews and MetaAnalyses (PRISMA) criteria. The risk of bias in primary studies was assessed by Cochrane's method. Heterogeneity of pooled prevalence was calculated using the chi-square test on Cochrane's Q statistic, which was quantified by I-square values. The random-effects analyses of proportions were used to determine the pooled prevalence of DENV antibodies, antigen and RNA from eligible studies.
Results:Of these, 3 studies reported co-circulation of all the 4 serotypes, while 2 separately reported co-circulation of DENV-1 &2 and DENV-1 to -3. All the antibody-based studies had significantly high heterogeneity (I2 >90%, P <0.05), while the NS1 and PCR-based studies had low heterogeneity (I2 <25%, P >0.05). The pooled prevalence of DENV IgM, IgG, RNA, NS1 and neutralizing antibodies were 16.8%, 34.7%, 7.7%, 7.7% and 0.7%, respectively. Southeast Nigeria had the highest pooled DENV-IgG seropositivity, 77.1%. Marital status, gender, educational level and occupation status, the proximity of residence to refuse dumpsite, frequent use of trousers and long sleeve shirts were significantly associated with DENV IgG seropositivity (P <0.05).
Conclusion:Based on these findings, it can be inferred that Nigeria is hyperendemic for Dengue fever and needs concerted efforts to control its spread within and outside the country.
