Newer Neuroleptic Treatment in Behavioral and Psychological Symptoms of Dementia.
- Author:
Jung Hyun LEE
1
;
Byoung Hoon OH
;
Kae Joon YOO
Author Information
1. Department of Psychiatry, Yonsei University, College of Medicine, Seoul, Korea. DROBH@Chollian.net
- Publication Type:Original Article
- Keywords:
Elderly dementia patient;
BPSD;
Risperidone;
Olanzapine;
Efficacy;
Safety
- MeSH:
Aged;
Alzheimer Disease;
Checklist;
Dementia*;
Dementia, Vascular;
Female;
Humans;
Incidence;
Male;
Risperidone;
Treatment Outcome
- From:Korean Journal of Psychopharmacology
2000;11(3):232-237
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the treatment efficacy and safety of risperidone and olanzapine in elderly dementia patients. METHODS: The study population consisted of 42 elderly patients in BPSD (Behavioral and Psychological Symptoms of Dementia) with dementia for 'risperidone' and 'olanzapine' treatment. Clinical safety and efficacy were evaluated by CGI (Clinical Global Impression) and the side effects checklist. RESULTS: The mean subject age was 68.2+/-5.9 consisting of 16 (38.1%) males and 26 (61.9%) females. The types of dementia among the 42 demented patients were as follows: 30 (71.5%) with Alzheimer's disease, 5 (11.9%) with vascular dementia, and 7 (16.7%) with unclassified dementia. The efficacy of risperidone and olanzapine was "marked improved 14.9% vs 34.0%", "moderately improved 45.2% vs 29.9%", and "mildly improved 30.3% vs 36.1%" by CGI. The incidence of adverse reaction was 25.8% vs 36.3%, respectively. CONCLUSION: Risperidone and olanzapine demonstrated highly useful and presented to be a well tolerated antipsychotic drug for behavioral and psychological symptoms of dementia between 1-2 mg vs 5-7.5 mg per daily dosage, respectively. However proper evaluation of mini-mental state examination, IADL (Instrumental Activities of Daily Living) and larger number of elderly patients must be analyzed.
