Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
10.7774/cevr.2020.9.2.159
- Author:
Lucía Daniela GRIPPO
1
;
Ivana Gabriela REIDEL
;
María Inés GARCÍA
;
Alexis STREU
;
Diana María MÜLLER
;
Carolina Melania VEAUTE
Author Information
1. LAQUIMAP, Dto. Química Orgánica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
- Publication Type:Brief communication
- From:Clinical and Experimental Vaccine Research
2020;9(2):159-163
- CountryRepublic of Korea
- Language:English
-
Abstract:
The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming Gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules.
