The Effect of Polygalasaponins in Polygalae Tenuifolia on Apomorphine-Induced Hyperlocomotions in Mice.
- Author:
In Won CHUNG
1
;
Won Keun OH
;
Yong Sik KIM
;
Joo Bae PARK
;
Jong Seog AHN
;
Hyun Sun LEE
;
Woon Taek KIM
;
Chang In LEE
Author Information
1. Department of Neuropsychiatry, College of Medicine, Chungbuk National University, Cheongju, Korea.
- Publication Type:Original Article
- Keywords:
Polygalae tenuifolia;
Polygalasaponins;
Apomorphine;
Stereotyped behaviors;
Climbing behavior
- MeSH:
Animals;
Apomorphine;
Biological Products;
Chromatography;
Magnetic Resonance Spectroscopy;
Medicine, Traditional;
Mice*;
Models, Animal;
Polygala*;
Psychotic Disorders;
Stereotyped Behavior
- From:Korean Journal of Psychopharmacology
2000;11(3):254-261
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study was to investigate in vivo antidopaminergic activities of polygalasaponins which included in the roots of Polygalae tenuifolia, one of the natural plants prescribed to treat psychotic disorders in traditional medicine. METHODS: The chemical separations were conducted by chromatographies with various columns and the chemical structures were identified using spectroscopy, NMR and so on. The apomorphine-induced stereotyped behaviors and climbing behaviors in mice as animal models of psychotic disorders were applied to explore the antidopaminergic activity. RESULTS: The active compounds with antidopaminergic effects in the roots of Polygalae tenuifolia were identified as polygalasaponin A-D. The polygalasaponins showed to suppress the apomorphine-induced stereotyped behaviors and climbing behaviors in dose-related fashions. CONCLUSION: This study suggests that polygalasaponins might have antipsychotic activities. The natural products need to be explored extensively as sources of new medications in psychiatric fields. Further explorations for chemical and pharmacological properties of polygalasaponins are required.
