The Change of Cerebral Metabolites in Patients with Parkinson's Disease Measured by Proton Magnetic Resonance Spectroscopy.
- Author:
Jong Ki KIM
1
;
Byeong Chae KIM
;
Kee Ra LEE
;
Min Kyung SONG
;
Man Seok PARK
;
Myeong Kyu KIM
;
Ki Hyun CHO
;
Jeong Jin SEO
Author Information
1. Department of Neurology, Chonnam National University Medical School, and Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. kcho@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Parkinson's disease;
Magnetic resonance spectroscopy (MRS)
- MeSH:
Aspartic Acid;
Basal Ganglia;
Diagnosis;
Humans;
Lactic Acid;
Magnetic Resonance Spectroscopy*;
Parkinson Disease*;
Protons*;
Thalamus
- From:Journal of the Korean Neurological Association
2003;21(6):622-627
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Parkinson's disease is a progressive, common neuro-degenerative disorder of the extrapyramidal system leading to specific motor symptoms, but there is no specific early diagnostic tool. This study was aimed to investigate the change of cerebral metabolites in patients with parkinson's disease by 1H magnetic resonance spectroscopy (MRS). METHODS: Eighteen patients with idiopathic unilateral symptomatic parkinson's disease underwent MRS study to compare metabolites of basal ganglia and thalamus, in ipsilateral and contralateral to the clinically affected side. RESULTS: In patients with unilateral symptomatic parkinson's disease, N-acetyl aspartate (NAA)/Creatine (Cr) ratio was significantly lower in contralateral side to the clinically affected side than in ipsilateral side (p=0.023). Other cerebral metabolites (Cho, mI, alpha-Glx, beta-Glx, lactate, lipid) were showed no significant difference in patients with parkinson's disease. CONCLUSIONS: The comparison and quantification of cerebral metabolites by using MRS may be helpful to diagnosis and investigation of parkinson's disease.
