Prognostic Stratification of Patients with Burkitt Lymphoma Using Serum β2-microglobulin Levels
- Author:
Hyung-Don KIM
1
;
Hyungwoo CHO
;
Shin KIM
;
Kyoungmin LEE
;
Eun Hee KANG
;
Jung Sun PARK
;
Chan-Sik PARK
;
Jooryung HUH
;
Jin Sook RYU
;
Sang-Wook LEE
;
Dok-Hyun YOON
;
Seok Jin KIM
;
Young Hyeh KO
;
Won Seog KIM
;
Cheolwon SUH
Author Information
- Publication Type:Original Article
- From:Cancer Research and Treatment 2021;53(3):847-856
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:We aimed to investigate the prognostic value of serum β2-microglobulin for patients with Burkitt lymphoma (BL) and to propose a risk-stratifying classification system.
Materials and Methods:A prospective registry-based cohort study of BL patients treated with dose-intensive or effective dose-adjusted chemotherapies (n=81) was conducted. Survival outcomes were compared based on previously reported risk groups and/or serum β2-microglobulin levels. A risk-stratifying classification system incorporating serum β2-microglobulin levels was proposed and validated in an independent validation cohort (n=60).
Results:The median age was 47 years, and 57 patients (70.4%) were male. Patients with high serum β2-microglobulin levels (> 2 mg/L) had significantly worse progression-free survival (PFS) and overall survival (OS) (p < 0.01 for both). Serum β2-microglobulin levels further stratified patients in the low-risk and high-risk groups in terms of PFS (p=0.010 and p=0.044, respectively) and OS (p=0.014 and p=0.026, respectively). Multivariate analyses revealed that a high serum β2-microglobulin level (> 2 mg/L) was independently associated with a shorter PFS (hazards ratio [HR], 3.56; p=0.047) and OS (HR, 4.66; p=0.043). The new classification system incorporating the serum β2-microglobulin level allowed the stratification of patients into three distinct risk subgroups with 5-year OS rates of 100%, 89.5%, and 62.5%. In an independent cohort of BL, the system was validated by stratifying patients with different survival outcomes.
Conclusion:Serum β2-microglobulin level is an independent prognostic factor for BL patients. The proposed β2-microglobulin–based classification system could stratify patients with distinct survival outcomes, which may help define appropriate treatment approaches for individual patients.
