Clinical impact of lymphatic spread in patients with limited-stage upper aerodigestive tract NK/T cell lymphoma
- Author:
Moo-Kon SONG
1
;
Joo-Seop CHUNG
;
Sung-Yong OH
;
Sung-Nam LIM
;
Won-Sik LEE
;
Sang-Min LEE
;
Do-Young KIM
Author Information
- Publication Type:ORIGINAL ARTICLE
- From:Blood Research 2021;56(2):72-78
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:We investigated whether distance max , that is, the degree of distance between the upper aerodigestive tract (UAT) mass and the farthest pathologic lymph node, was significantly associated with survival in patients with limited-stage UAT natural killer/T cell lymphoma (NKTCL).
Methods:A total of 157 patients who received chemotherapy (CTx) with/without radiotherapy (RTx) were enrolled.
Results:In the survival analysis, an elevated lactate dehydrogenase level [progression-free survival (PFS): hazard ratio (HR), 2.948; 95% confidence interval (CI), 1.606‒5.404; P ＜0.001; overall survival (OS): HR, 2.619; 95% CI, 1.594‒4.822; P =0.003], short distance max (PFS: HR, 0.170; 95% CI, 0.071‒0.410; P ＜0.001; OS: HR, 0.142; 95% CI, 0.050‒0.402; P ＜ 0.001), and CTx combined with RTx (HR, 0.168; 95%CI, 0.079‒0.380; P < 0.001; OS: HR, 0.193; 95% CI, 0.087‒0.429; P ＜0.001) had an independent predictive value for PFS and OS.
Conclusion:The evaluation of the degree of lymphatic spread and local control by CTx combined with RTx is essential in patients with limited-stage UAT NKTCL.
