Extensive Nevus Comedonicus with Inflammatory Nodules and Cysts Controlled with Adalimumab

Author: Eun Hye LEE ¹ ; Seon Hwa LEE ; Chihyeon SOHNG ; Jun Young KIM ; Kyung Duck PARK ; Seok-Jong LEE ; Weon Ju LEE
Author Information

1. Department of Dermatology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea
Publication Type:CASE REPORT
From:Annals of Dermatology 2021;33(4):361-364
CountryRepublic of Korea
Language:English
Abstract: Nevus comedonicus is a very rare skin disorder characterized by the presence of comedo-like dilated pores with keratinous plugs, rarely resulting in painful recurrent inflammatory nodules or cysts. It presents as localized or extensive form. It displays unilaterally or bilaterally segmental distribution. Histopathologically, it is characterized by keratin-filled epidermal invagination with bulbous proliferation of keratinocytes. The condition may be caused by fibroblast growth factor receptor 2 mutation. Although it may be controlled by a variety of therapeutic modalities, it is difficult to achieve complete resolution. We report a case of extensive nevus comedonicus with inflammatory nodules and cysts controlled with adalimumab.